Stemple D L, Anderson D J
Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown 02129.
Dev Biol. 1993 Sep;159(1):12-23. doi: 10.1006/dbio.1993.1218.
This review addresses the contribution of in vitro investigations to our understanding of neural crest development. Cell culture has been used to study the environmental control of cell lineage decisions in the neural crest and to define the developmental potentials of specific populations of neural crest and neural crest-derived cells. We consider the roles of environmental signals in the context of the development of several different neural crest-derived lineages. We also discuss evidence for influences of local cell-cell interactions and substrate molecules on neural crest development. Data bearing on the issues of neural crest cell multipotency, self-renewal, and lineage commitment are reviewed.
本综述阐述了体外研究对我们理解神经嵴发育的贡献。细胞培养已被用于研究神经嵴中细胞谱系决定的环境控制，并确定特定神经嵴群体和神经嵴衍生细胞的发育潜能。我们在几种不同神经嵴衍生谱系的发育背景下考虑环境信号的作用。我们还讨论了局部细胞间相互作用和底物分子对神经嵴发育影响的证据。对有关神经嵴细胞多能性、自我更新和谱系定向问题的数据进行了综述。
