Pukhalsky A L, Toptygina A P, Viktorov V V
Laboratory of Immunogenetics, National Research Center of Medical Genetics, Moscow, Russia.
Int J Immunopharmacol. 1993 May;15(4):509-14. doi: 10.1016/0192-0561(93)90065-7.
Mechanisms of strain differences in susceptibility to cyclophosphamide (CP) has been investigated with BALB/c, DBA/2, CC57BR, and C57BL/6 mice. It was shown that the final immunosuppressive effects of CP is a result of a combination of such factors as the level of CP alkylating metabolites in the bloodstream and the sensitivity of the target cells to antiproliferative action of these metabolites. The importance of the immune status peculiarities has been discussed.
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