Leibowitz D
Department of Medicine, Mount Sinai Medical Center, New York, New York.
J Clin Pharmacol. 1993 Jun;33(6):508-12. doi: 10.1002/j.1552-4604.1993.tb04696.x.
Initially synthesized in 1960, sotalol is a novel beta-adrenoreceptor blocking agent that also possesses class III anti-arrhythmic properties. The drug's ability to lengthen repolarization and prolong effective refractory periods in all cardiac tissues in addition to its beta-blocking effects make sotalol an attractive agent for use in a variety of supraventricular and ventricular arrhythmias.