Supple W F, Kapp B S
Department of Psychology, University of Vermont, Burlington 05405.
J Neurosci. 1993 Sep;13(9):3705-11. doi: 10.1523/JNEUROSCI.13-09-03705.1993.
The effects of lesions of the cerebellum on the acquisition and retention of aversive Pavlovian conditioned bradycardia were examined in rabbits. Lesions of the anterior cerebellar vermis severely attenuated the acquisition of simple conditioned bradycardia without disrupting baseline heart rate (HR), or unconditioned HR responses. Also, lesions of the vermis performed after the acquisition of conditioned bradycardia eliminated evidence of prior conditioning. Bilateral lesions of the cerebellar hemispheres did not affect conditioned or unconditioned HR responses. These results were interpreted to indicate that anterior vermis lesions specifically disrupted part of an essential conditioned response pathway without interfering with the neural circuits that mediate unconditioned HR responding. These lesion data, coupled with recent electrophysiological evidence of learning-related changes in neuronal activity within the anterior vermis of the fear-conditioned rabbit, suggest that the anterior cerebellar vermis is critically involved in the acquisition and retention of this rapidly learned autonomic conditioned response.
在兔子身上研究了小脑损伤对厌恶性巴甫洛夫条件性心动过缓的获得和保持的影响。小脑前蚓部损伤严重削弱了简单条件性心动过缓的获得，而不干扰基线心率（HR）或非条件性HR反应。此外，在获得条件性心动过缓后进行的蚓部损伤消除了先前条件作用的证据。小脑半球的双侧损伤不影响条件性或非条件性HR反应。这些结果被解释为表明前蚓部损伤特异性地破坏了基本条件反应通路的一部分，而不干扰介导非条件性HR反应的神经回路。这些损伤数据，再加上最近关于恐惧条件化兔子前蚓部神经元活动中与学习相关变化的电生理证据，表明小脑前蚓部在这种快速习得的自主条件反应的获得和保持中起关键作用。
