哺乳动物视网膜中带轴突的水平细胞意外出现神经丝。
Unexpected presence of neurofilaments in axon-bearing horizontal cells of the mammalian retina.
作者信息
Peichl L, González-Soriano J
机构信息
Max-Planck-Institut für Hirnforschung, Frankfurt/M., Germany.
出版信息
J Neurosci. 1993 Sep;13(9):4091-100. doi: 10.1523/JNEUROSCI.13-09-04091.1993.
In several mammals only one of the two types of retinal horizontal cell, the axonless A-type, appears to express neurofilaments. Neurofilament immunostaining of rodent retinas reveals a horizontal cell plexus that has previously been interpreted as belonging to A-type cells. Our intracellular Lucifer yellow injections strongly suggest that there are no A-type horizontal cells in rat and gerbil. Counterstaining of dye-injected cellular structures with a neurofilament antibody directly shows that the axon terminal systems of the axon-bearing B-type horizontal cells contain neurofilaments. These unexpected findings explain and reinterpret the neurofilament plexus in rodent retinas. In contrast, Lucifer yellow injections in guinea pig retina reveal both A- and B-type horizontal cells, showing that horizontal cell types are not uniform among rodents. In the guinea pig retina both A-type cells and B-type axon terminal systems contain neurofilaments.
在几种哺乳动物中，视网膜的两种水平细胞类型中只有无轴突的 A 型细胞似乎表达神经丝。对啮齿动物视网膜进行神经丝免疫染色，可揭示一个水平细胞丛，该丛以前被解释为属于 A 型细胞。我们的细胞内 Lucifer 黄注射结果强烈表明，大鼠和沙鼠中不存在 A 型水平细胞。用神经丝抗体对注射染料的细胞结构进行复染，直接显示出有轴突的 B 型水平细胞的轴突终末系统含有神经丝。这些意外发现解释并重新诠释了啮齿动物视网膜中的神经丝丛。相比之下，对豚鼠视网膜进行 Lucifer 黄注射可揭示 A 型和 B 型水平细胞，表明啮齿动物之间的水平细胞类型并不一致。在豚鼠视网膜中，A 型细胞和 B 型轴突终末系统均含有神经丝。
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