Shimoda O, Kano T, Takaki M, Tashima T, Tashiro M, Ikuta Y, Morioka T, Nakano M, Mishima M
Department of Anesthesiology, Kumamoto Rosai Hospital, Yatsushiro.
Masui. 1993 Aug;42(8):1171-6.
We have developed transdermally applicable 10% lidocaine aqueous gel containing an absorption promoter and applied it for 15 patients suffering from severe pain in acute or subacute phase of herpes zoster. The patients, consisting of 7 males and 8 females with a mean age 58.5 +/- 13.0 (SD) yrs, had skin eruptions of herpes zoster for the past 2 months. Lidocaine-gel was applied locally to the diseased skin with or without an occlusive dressing. In 14 of the 15 patients (93%), a remarkable reduction of pain (below 10% of pretreatment level) was obtained after 9.9 +/- 5.6 (SD) times of lidocaine-gel treatments. There was no adverse systemic reactions or local skin damages. None of them developed post-herpetic neuralgia. The lidocaine-gel treatment appears to be very useful for reduction of pain associated with acute or subacute phase of herpes zoster.
我们研发了一种含有吸收促进剂的10%利多卡因水凝胶透皮制剂，并将其应用于15例患有带状疱疹急性期或亚急性期严重疼痛的患者。患者包括7名男性和8名女性，平均年龄58.5 +/- 13.0（标准差）岁，过去两个月患有带状疱疹皮疹。利多卡因凝胶在有或没有封闭敷料的情况下局部应用于患病皮肤。15例患者中有14例（93%）在接受9.9 +/- 5.6（标准差）次利多卡因凝胶治疗后，疼痛显著减轻（降至治疗前水平的10%以下）。未出现全身性不良反应或局部皮肤损伤。他们均未发生带状疱疹后神经痛。利多卡因凝胶治疗似乎对减轻带状疱疹急性期或亚急性期相关疼痛非常有效。
