Karnafel W
Kliniki Gastroenterologii i Chorób Przemiany Materii Akademii Medycznej, Warszawie.
Kardiol Pol. 1993 May;38(5):341-5.
The effect of sodium dichloroacetate on the size of myocardial infarction and on the changes of blood lactate and pyruvate levels after coronary artery occlusion were studies in 5 dogs. Sodium dichloroacetate administrated during coronary artery occlusion in dogs limited the size of myocardial necrotic area, simultaneous decrease of lactate and pyruvate levels in peripheral blood was observed. An analysis of lactate levels in blood samples from the coronary sinus and left atrium during coronary artery occlusion and the administration of sodium dichloroacetate suggests that the utilization of lactate by left ventricular myocardium under these conditions is increased.
在5只狗身上研究了二氯醋酸钠对心肌梗死面积以及冠状动脉闭塞后血乳酸和丙酮酸水平变化的影响。在狗冠状动脉闭塞期间给予二氯醋酸钠，可限制心肌坏死区域的大小，同时观察到外周血中乳酸和丙酮酸水平降低。对冠状动脉闭塞及给予二氯醋酸钠期间冠状窦和左心房血样中乳酸水平的分析表明，在这些条件下左心室心肌对乳酸的利用增加。
