Di Paolo N, Guarnieri A, Loi F, Sacchi G, Mangiarotti A M, Di Paolo M
Nephrology and Dialysis Department, Regional Hospital of Siena, Italy.
Nephron. 1993;64(4):621-5. doi: 10.1159/000187411.
Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending 8 h in a granary which had been closed for several months, a farmer and his wife suffered temporary respiratory distress; 24 h later, the woman developed nonoliguric ARF and biopsy revealed tubulonecrosis which healed in 24 days. Toxic substances were not found, but a strain of A. ochraceus producing ochratoxin was isolated from the wheat.
考古学家在打开埃及古墓后离奇死亡，有人怀疑这是吸入霉菌毒素所致，然而这一假设从未得到证实。最近，我们观察到一例急性肾衰竭（ARF）病例，明确是由于吸入了赭曲霉的赭曲霉毒素所致。一名农民和他的妻子在一个关闭了几个月的谷仓里待了8小时后，出现了短暂的呼吸窘迫；24小时后，该女子发展为非少尿型急性肾衰竭，活检显示肾小管坏死，并在24天内痊愈。未发现有毒物质，但从小麦中分离出了一株能产生赭曲霉毒素的赭曲霉。
