Calderón E, Hernández M, González N, Cob C, Martínez E
Bol Med Hosp Infant Mex. 1977 Jan-Feb;34(1):117-28.
Clinical and autopsy data indicate that ventriculitis persists despite parenteral and intralumbar antibiotic therapy. In the present study, ventriculitis was documented as postmortem examination in nine newborns. These studies indicate that ventriculitis occurs commonly in neonates with meningitis, particularly when there is delayed sterilization of CSF culture, A clinician has to bear in mind the diagnosis of ventriculitis when: 1) There is poor clinical and/or laboratory response to the usual therapy. 2) He has a critically ill patient with lethargy, convulsions and bulging fontanels. 3) He culture an unusual organism. 4) He faces a suspected complication of meningitis: subdural effusion, ventriculitis or abscess. 5) A CSF from ventricular puncture with more than 150 WBC, glucose less than 50 mg. and protein more than 200 mg.
临床和尸检数据表明,尽管采用了肠胃外和腰椎内抗生素治疗,脑室炎仍持续存在。在本研究中,9名新生儿经尸检证实患有脑室炎。这些研究表明,脑室炎常见于患有脑膜炎的新生儿,尤其是脑脊液培养延迟无菌化时。临床医生在以下情况时必须牢记脑室炎的诊断:1)对常规治疗的临床和/或实验室反应不佳。2)他有一名患有嗜睡、惊厥和囟门隆起的危重病患者。3)他培养出一种不常见的生物体。4)他面临脑膜炎的疑似并发症:硬膜下积液、脑室炎或脓肿。5)脑室穿刺获取的脑脊液白细胞超过150个、葡萄糖低于50毫克且蛋白质超过200毫克。