Gilles F H, Jammes J L, Berenberg W
Arch Neurol. 1977 Sep;34(9):560-2. doi: 10.1001/archneur.1977.00500210062011.
We reviewed autopsies of neonates who had died of meningitis. Plexitis and ventricular exudate were usually present. While the pathogenetic relationship between these two phenomena is uncertain, it is possible that the glycogen-rich choroid plexus of the lateral ventricles not only facilitates local bacterial growth but also acts as a bacterial reservoir relatively resistant to antimicrobial agents. We suggest that more drastic approaches than parenteral antimicrobial therapy may be indicated to reduce further the morbidity and mortality of neonatal meningitis.
我们回顾了死于脑膜炎的新生儿的尸检情况。通常存在脉络丛炎和脑室渗出物。虽然这两种现象之间的发病机制关系尚不确定，但侧脑室富含糖原的脉络丛不仅可能促进局部细菌生长，还可能作为相对耐药的细菌储存库。我们建议，可能需要采取比肠外抗菌治疗更激进的方法，以进一步降低新生儿脑膜炎的发病率和死亡率。
