Poulsen S S, Szabo S
Br J Exp Pathol. 1977 Feb;58(1):1-8.
Acute duodenal ulcer can be produced in the rat by subcutaneous or oral administration of cysteamine. Development of this ulcer on the intestinal mucosal surface was followed from precursory stages to perforation using low power semimacroscopical and conventional histological techniques. The process started in the epithelium of the apical parts of the villi where segments of surface epithelial cells exfoliated and the lamina propria seemed to retract. As the process continued the villi gradually became lower eventually forming an avillous surface. Subsequently defects in the epithelium, necrosis, inflammation of the lamina propria, and a localized ulcer developed.
通过皮下或口服半胱胺可在大鼠中诱发急性十二指肠溃疡。利用低倍半宏观和传统组织学技术，追踪该溃疡在肠黏膜表面从前期阶段到穿孔的发展过程。该过程始于绒毛顶端部分的上皮，此处表面上皮细胞片段脱落，固有层似乎回缩。随着过程的持续，绒毛逐渐变低，最终形成无绒毛表面。随后上皮出现缺损、坏死、固有层炎症，并发展为局部溃疡。
