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急性十二指肠溃疡形成过程中的组织学分级及连续形态学变化

Histological grading and sequential morphological changes during the production of acute duodenal ulcers.

作者信息

Rao S S, Joffe S N

出版信息

Br J Exp Pathol. 1979 Aug;60(4):411-6.

PMID:508591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041481/
Abstract

A method of grading histological changes in the duodenum and the sequential morphological appearances during the development of acute duodenal ulceration is described. After s.c. infusion of ulcerogenic doses of gastric secretagogues, rats were killed hourly and the duodenal lesions were graded from 1, which was the earliest change seen consisting of focal necrosis of the tips of villi to 6, which showed perforation of duodenal ulcer. For the first 4 h the duodenum was normal but after this there was progressive necrosis of the mucosa and submucosa, and inflammatory-cell infiltration. From 18 h rats were shown to have duodenal ulcers with or without perforation.

摘要

本文描述了一种对十二指肠组织学变化进行分级的方法，以及急性十二指肠溃疡形成过程中的连续形态学表现。在皮下注射致溃疡剂量的胃促分泌素后，每小时处死大鼠，并将十二指肠病变从1级开始分级，1级是最早出现的变化，表现为绒毛尖端局灶性坏死，直至6级，即十二指肠溃疡穿孔。最初4小时十二指肠正常，但此后黏膜和黏膜下层出现进行性坏死，并伴有炎症细胞浸润。从18小时起，大鼠出现有或无穿孔的十二指肠溃疡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/e5db4b295487/brjexppathol00124-0078-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/04b12fb59040/brjexppathol00124-0076-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/0fbc1b43d068/brjexppathol00124-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/e5db4b295487/brjexppathol00124-0078-c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/33494617e10e/brjexppathol00124-0076-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/f12bcf05d5be/brjexppathol00124-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/2f9d2ab6ed5c/brjexppathol00124-0077-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/db981df791de/brjexppathol00124-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/0fbc1b43d068/brjexppathol00124-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89a8/2041481/e5db4b295487/brjexppathol00124-0078-c.jpg

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本文引用的文献

1
Prevention of duodenal ulcers by administration of prostaglandin E 2 (PGE 2 ).通过给予前列腺素E2（PGE2）预防十二指肠溃疡。
Scand J Gastroenterol. 1971;6(4):303-5. doi: 10.3109/00365527109181124.
2
Production by secretagogues of duodenal ulcers in the rat.促分泌素对大鼠十二指肠溃疡的影响。
Gastroenterology. 1970 Jul;59(1):95-102.
3
Natural history and morphology of secretagogue-induced duodenal ulcers in rats.促分泌素诱导的大鼠十二指肠溃疡的自然病史和形态学
Gastroenterology. 1975 Oct;69(4):903-10.
4
Vagotomy and experimental duodenal ulcers.迷走神经切断术与实验性十二指肠溃疡
Acta Hepatogastroenterol (Stuttg). 1976 Nov-Dec;23(6):435-40.
5
Secretagogue-produced duodenal ulcers in the rat.促分泌素诱导的大鼠十二指肠溃疡
Br J Surg. 1977 Mar;64(3):218-20. doi: 10.1002/bjs.1800640320.
6
The effect of GIH and Boots secretin and cholecystokinin on duodenal ulcers in the rat.生长抑素、布茨促胰液素和胆囊收缩素对大鼠十二指肠溃疡的作用。
Acta Hepatogastroenterol (Stuttg). 1977 Dec;24(6):458-61.
7
Gastrin, antral g cells, and gastric acid in secretagogue-induced and antihistamine-inhibited duodenal ulcers.促分泌素诱导和抗组胺药抑制的十二指肠溃疡中的胃泌素、胃窦G细胞和胃酸
Scand J Gastroenterol. 1977;12(1):27-32.