Wilhelmi G
Z Rheumatol. 1993 May-Jun;52(3):174-9.
Owing to the methodological difficulties involved, none of the studies so far published on the influence of diet on human osteo-arthritis has been fully comprehensive. We have therefore compiled a series of experimental observations--including some of our own--in the mouse and other species that have a bearing on this subject. Fats with a high content of saturated fatty acids, such as pork fat, greatly favored the development of spontaneous osteo-arthritis in the mouse, as also did cholesterol. Cottonseed oil and olive oil showed less tendency to do so. The highly unsaturated linoleic acid antagonized the effect of pork fat. Other vegetable oils and also fish oil exerted an anti-inflammatory and antinociceptive action in experimental animals. Foodstuffs rich in carbohydrates only promoted the development of degenerative joint disease in predisposed mice. Hyperglycemia (diabetes mellitus) constitutes a risk factor for the development of osteo-arthritis in humans as well as in mice and rats. A low-protein diet led to dysplasia of the hip joint in the dog; a high-protein diet inhibited the development of osteo-arthritis in the mouse, but promoted inflammation in volunteers. Disturbances of protein metabolism such as alkaptonuria can initiate degenerative processes in the joints of humans and animals.
由于存在方法学上的困难，迄今为止发表的关于饮食对人类骨关节炎影响的研究均未做到全面彻底。因此，我们整理了一系列实验观察结果——包括我们自己的一些观察结果——涉及小鼠及其他物种中与该主题相关的情况。饱和脂肪酸含量高的脂肪，如猪油，极大地促进了小鼠自发性骨关节炎的发展，胆固醇也是如此。棉籽油和橄榄油的这种倾向则较小。高度不饱和的亚油酸可对抗猪油的作用。其他植物油以及鱼油在实验动物中具有抗炎和抗伤害感受作用。富含碳水化合物的食物只会促进易患骨关节炎的小鼠发生退行性关节疾病。高血糖（糖尿病）是人类以及小鼠和大鼠发生骨关节炎的一个风险因素。低蛋白饮食会导致狗的髋关节发育异常；高蛋白饮食可抑制小鼠骨关节炎的发展，但会促进志愿者体内的炎症反应。蛋白质代谢紊乱，如尿黑酸尿症，可引发人和动物关节的退行性病变。
