Emerson J C, Salmon S E, Dalton W, McGee D L, Yang J M, Thompson F H, Trent J M
Arizona Cancer Center, University of Arizona, Tucson 85724.
Adv Exp Med Biol. 1993;330:107-18. doi: 10.1007/978-1-4615-2926-2_9.
We describe an ongoing study examining the relevance of cytogenetic changes in primary and metastatic breast cancer. Tumors samples from breast cancer patients are karyotype using G-banding techniques, and all chromosomal findings, including the presence of structural and numeric clonal abnormalities, are documented in a dynamic patient data base. Information on essential clinical characteristics is collected, and patients are followed longitudinally for disease recurrence, progression, and survival. Statistical analyses will examine potential correlations between specific abnormalities and clinical features of the disease, and survival differences between patients will be examined as a function of karyotypic differences. We anticipate that this research will provide insights on the natural history of breast cancer and help direct the search for the underlying molecular mechanisms of tumor genesis and progression.
我们描述了一项正在进行的研究，该研究旨在探讨细胞遗传学改变在原发性和转移性乳腺癌中的相关性。使用G显带技术对乳腺癌患者的肿瘤样本进行核型分析，所有染色体检查结果，包括结构和数目克隆异常的存在情况，都记录在一个动态的患者数据库中。收集基本临床特征的信息，并对患者进行长期随访，以观察疾病复发、进展和生存情况。统计分析将检验特定异常与疾病临床特征之间的潜在相关性，并根据核型差异检验患者之间的生存差异。我们预计这项研究将为乳腺癌的自然史提供见解，并有助于指导寻找肿瘤发生和进展的潜在分子机制。
