Pilar Honrubia M, Paz Herráez M, Alvarez R
Dpto. Biología Celular y Anatomía, Universidad de León, Spain.
Arch Environ Contam Toxicol. 1993 Aug;25(2):184-91. doi: 10.1007/BF00212129.
Embryos of Rana perezi were kept under laboratory conditions and treated with carbamate ZZ-Aphox at chronic doses of 0.02% and 0.14% for 9 weeks. Both the histological study and the analysis of mortality show a direct relationship between the dosage and the effects of the pesticide. The histological study of the survivors over 56 days show damages in gills, liver, gall-bladder, heart, and notochord. Damages on the epithelial of gills (on their distal portion) and gall-bladder recover over a few days, whereas those provoked on the compacting of the hepatic parenchyma and the hepatocytes, the auricle and the perintocohordal collagenic fibers alter their structure in a lasting way. Potentials of such alterations are discussed, with special reference to the possible interference of the pesticide on the successful synthesis of the supporting connective sheaths.
将泽陆蛙胚胎置于实验室条件下，用氨基甲酸酯类农药ZZ - Aphox以0.02%和0.14%的慢性剂量处理9周。组织学研究和死亡率分析均表明农药剂量与效应之间存在直接关系。对存活超过56天的胚胎进行组织学研究发现，鳃、肝脏、胆囊、心脏和脊索均有损伤。鳃上皮（远端部分）和胆囊的损伤在数天内恢复，而肝实质和肝细胞的致密化、心耳以及脊索周围胶原纤维所引发的损伤则会持久改变其结构。本文讨论了这些改变的可能性，特别提及了该农药可能对支持性结缔组织鞘的成功合成产生的干扰。
