Mengs U, Stotzem C D
Toxicology and Experimental Pathology, Madaus AG, Köln, Germany.
Arch Toxicol. 1993;67(5):307-11. doi: 10.1007/BF01973700.
The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functionally, there were rises in plasma creatinine and urea together with increases in urinary glucose, protein, N-acetyl-beta-glucosaminidase, gammaglutamyl transferase and malate dehydrogenase. Taking AA as an example, the aim of the present study was to consider the suitability of this model, based on a combination of histology and laboratory investigations, as a short-term test for the detection of nephrotoxic agents.
通过胃管给雌性Wistar大鼠单剂量10、50或100 mg/kg马兜铃酸（AA），研究其肾毒性作用。3天内出现肾损伤，且作用呈剂量依赖性。组织学上，有肾小管上皮坏死的证据；功能上，血浆肌酐和尿素升高，同时尿葡萄糖、蛋白质、N-乙酰-β-葡萄糖苷酶、γ-谷氨酰转移酶和苹果酸脱氢酶增加。以AA为例，本研究的目的是基于组织学和实验室检查相结合，考虑该模型作为检测肾毒性药物的短期试验的适用性。
