Tominaga T, Yoshida Y, Kosaki G, Kurihara M
Department of Surgery, Tokyo Metropolitan Komagome Hospital.
Jpn J Cancer Res. 1993 Jul;84(7):783-6. doi: 10.1111/j.1349-7006.1993.tb02044.x.
Effects of 5-fluorouracil (5-FU) and UFT on an experimental liver metastasis model were compared at equi-effective dosage levels against subcutaneous tumor of mouse colon 26. 5-FU at the dosage level of 40 mg/kg suppressed the subcutaneous tumor growth by 70.0% and 45.0% on day 13 and day 18, respectively, and UFT at 20 mg/kg provided almost equal suppression (63.0% and 48.0%). In the liver metastasis model, 5-FU at 40 mg/kg showed more potent prevention of the formation of metastatic foci (94.9%) than did UFT (60.4%) at 20 mg/kg. 5-FU at 40 mg/kg produced a much higher peak serum level of 5-FU than did UFT at 20 mg/kg and also showed a much higher AUC (area under the curve) level in the portal blood. These results suggest that oral administration of 5-FU might be useful in prevention of liver metastasis of colorectal cancer.
在对小鼠结肠26皮下肿瘤的等效剂量水平上，比较了5-氟尿嘧啶（5-FU）和优福定（UFT）对实验性肝转移模型的影响。5-FU剂量为40mg/kg时，在第13天和第18天分别抑制皮下肿瘤生长70.0%和45.0%，而20mg/kg的UFT产生了几乎相同的抑制效果（63.0%和48.0%）。在肝转移模型中，40mg/kg的5-FU比20mg/kg的UFT更有效地预防转移灶形成（94.9%比60.4%）。40mg/kg的5-FU产生的血清5-FU峰值水平比20mg/kg的UFT高得多，并且门静脉血中的曲线下面积（AUC）水平也高得多。这些结果表明，口服5-FU可能有助于预防结直肠癌的肝转移。
