Hetland M L, Haarbo J, Christiansen C
Center for Clinical and Basic Research, Ballerup, Denmark.
J Clin Endocrinol Metab. 1993 Sep;77(3):770-5. doi: 10.1210/jcem.77.3.8370698.
Running is a popular sport, but in some studies long distance running in women has been related to reduced bone mass and a potential risk of osteoporosis. To investigate the impact of running on bone mass in men, 120 healthy, physically active men (19-56 yr old; running 0-160 km/week) were studied. Bone mineral content was measured in the lumbar spine, total body, and proximal femurs by dual energy x-ray absorptiometry and in the forearm by single photon absorptiometry. Bone turnover was assessed by urinary pyridinium cross-links, plasma osteocalcin, and serum alkaline phosphatase. Lumbar bone mineral content was negatively correlated to the weekly distance run (r = -0.37; P < 0.0001), with a difference of 19 +/- 5% (mean +/- SEM) between controls and elite runners. A similar relation was found for all measurement sites. After adjustment for possible confounders, the correlations remained statistically significant in areas with a high proportion of trabecular bone. Bone turnover parameters were 20-30% higher in the elite runners, whereas sex hormone status was unrelated to running activity. We conclude that male long distance runners had reduced bone mass and increased bone turnover compared to controls, which suggests accelerated bone loss. The pathophysiological explanation was not clear, but sex hormones did not seem to play a key role.
跑步是一项广受欢迎的运动，但在一些研究中，女性长跑与骨量减少及骨质疏松的潜在风险有关。为了研究跑步对男性骨量的影响，对120名健康、有体育活动习惯的男性（年龄19 - 56岁；每周跑步0 - 160公里）进行了研究。通过双能X线吸收法测量腰椎、全身和股骨近端的骨矿物质含量，通过单光子吸收法测量前臂的骨矿物质含量。通过尿吡啶交联、血浆骨钙素和血清碱性磷酸酶评估骨转换。腰椎骨矿物质含量与每周跑步距离呈负相关（r = -0.37；P < 0.0001），对照组和精英跑步者之间的差异为19±5%（均值±标准误）。在所有测量部位都发现了类似的关系。在对可能的混杂因素进行调整后，在小梁骨比例高的区域，相关性仍具有统计学意义。精英跑步者的骨转换参数高出20 - 30%，而性激素状态与跑步活动无关。我们得出结论，与对照组相比，男性长跑运动员的骨量减少且骨转换增加，这表明骨质流失加速。其病理生理学解释尚不清楚，但性激素似乎并未起关键作用。
