Goldin K R
Department of Family and Preventive Medicine, Meharry Medical College, Nashville, TN.
J Natl Med Assoc. 1993 Aug;85(8):617-20.
Maternal consumption of casein is associated with excess low birthweight and infant mortality. Genetically normal infants of hyperphenylalaninemic mothers also show excess low birthweight and mortality. To determine whether the phenylalanine in casein could produce a secondary phenylketonuria effect, maternal serum phenylalanine levels were measured in 77 specimens of maternal blood serum drawn during the 15th through 21st weeks of pregnancy and in 55 specimens of cord [correction of cold] blood collected from the same mothers' infants. Maternal serum phenylalanine levels correlated negatively with infant birthweight in the 41 infants for whom appropriate confounders were known. Infant serum phenylalanine levels did not correlate with birthweight. Neither maternal nor infant serum phenylalanine levels correlated with 1-minute Apgar scores. A negative association was seen between both maternal and infant serum phenylalanine levels and 5-minute Apgar scores when appropriate confounders were controlled.
母体摄入酪蛋白与低出生体重和婴儿死亡率过高有关。高苯丙氨酸血症母亲所生的基因正常婴儿也表现出低出生体重和死亡率过高的情况。为了确定酪蛋白中的苯丙氨酸是否会产生继发性苯丙酮尿症效应，对77份孕15至21周期间采集的母体血清样本以及从同一母亲的婴儿采集的55份脐血样本中的母体血清苯丙氨酸水平进行了测量。在已知合适混杂因素的41名婴儿中，母体血清苯丙氨酸水平与婴儿出生体重呈负相关。婴儿血清苯丙氨酸水平与出生体重无相关性。母体和婴儿血清苯丙氨酸水平均与1分钟阿氏评分无相关性。当控制合适的混杂因素时，母体和婴儿血清苯丙氨酸水平与5分钟阿氏评分之间均呈负相关。
