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[对出生后早期接受应激或药物暴露测试的大鼠中去甲肾上腺素的体温调节反应]

[The thermoregulatory response to noradrenaline in rats tested for stress or pharmacological exposures in the early postnatal period].

作者信息

Moshkin M P, Seliatitskaia V G, Zhigulina E I, Arshinova T V

出版信息

Ontogenez. 1993 Jul-Aug;24(4):68-74.

PMID:8371906
Abstract

Norepinephrine-induced increase of the thermoconductivity of the body surface was depressed in rats exposed to cold, handling or treatment with thyroid hormone or alpha-adrenomimetic (mezatone) during the first week after birth. This effect was enhanced by prolonged cold exposure of adult animals. On the contrary, the norepinephrine-induced increase of heat losses from the tail surface was higher in new-born rats, exposed to cold or treated with beta-adrenomimetic (novodrine) than in control or mezatone-treated groups. The effects of neonatal stress or pharmacological treatment on oxygen consumption and rectal temperature responses to norepinephrine were unsignificant.

摘要

出生后第一周暴露于寒冷、接受处理或用甲状腺激素或α-肾上腺素能激动剂(美加明)治疗的大鼠,去甲肾上腺素诱导的体表热导率增加受到抑制。成年动物长时间暴露于寒冷环境会增强这种效应。相反,与对照组或接受美加明治疗的组相比,暴露于寒冷或用β-肾上腺素能激动剂(新福林)治疗的新生大鼠,去甲肾上腺素诱导的尾部表面热损失增加更高。新生儿应激或药物治疗对去甲肾上腺素引起的耗氧量和直肠温度反应的影响不显著。

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