Yi I, Bays M E, Stephan F K
Department of Psychology, Florida State University, Tallahassee 32310-1051.
Physiol Behav. 1993 Aug;54(2):375-81. doi: 10.1016/0031-9384(93)90126-z.
Rats were housed in activity wheels (n = 32) or in hanging cages (n = 32) for 2 weeks. Food intake of rats in hanging cages was curtailed to match body weight to that of the activity group. All rats then received 6 g of food at one of four different times of day (n = 8, each mealtime) for 4 consecutive days and were sacrificed 24 h after the last meal. Twenty-three rats in the activity group and 13 rats in the hanging cage group had ulcers in the glandular portion of the stomach. Ulcers were significantly larger and more numerous in the activity group, and activity levels were highly correlated with area of ulceration. In both groups, terminal body weight was also significantly correlated with area of ulceration. No statistically reliable mealtime effects were observed because of large within-group variability. Because many rats in hanging cages developed ulcers in the absence of wheel running, the results suggest that restricted food supply and loss of body weight are initiating factors in ulcer formation, while excessive wheel running contributes to the severity of ulcerations in the glandular stomach.
将32只大鼠置于活动轮中，32只大鼠置于悬挂笼中，持续2周。限制悬挂笼中大鼠的食物摄入量，使其体重与活动组大鼠体重相匹配。然后，所有大鼠在一天中的四个不同时间之一（每个用餐时间8只）连续4天每天喂食6克食物，并在最后一餐24小时后处死。活动组23只大鼠和悬挂笼组13只大鼠胃腺部出现溃疡。活动组的溃疡明显更大且更多，活动水平与溃疡面积高度相关。在两组中，终末体重也与溃疡面积显著相关。由于组内变异性较大，未观察到统计学上可靠的用餐时间效应。由于许多悬挂笼中的大鼠在没有转轮运动的情况下也出现了溃疡，结果表明食物供应受限和体重减轻是溃疡形成的起始因素，而过度的转轮运动则会加重胃腺部溃疡的严重程度。
