Watanabe K, Hara C, Ogawa N
Department of Pharmacology, Ehime University School of Medicine, Japan.
Jpn J Pharmacol. 1990 Mar;52(3):421-9. doi: 10.1254/jjp.52.421.
In the present study, the relationship between the development of activity-stress (A-S) ulcer and the behavioral and physical changes of rats with the A-S paradigm was investigated. We applied the endoscopic technique to establish the A-S ulcer as a model for studying the therapeutic or healing process of ulcers. Male and female rats were subjected to daily 1 hr feeding in the light (L)-phase (09:00-10:00) or in the dark (D)-phase (21:00-22:00). Prior to peak-revolution of running-activity, ulcer occurred earlier in the L-phase feeding group than in the D-phase feeding group. The ulcer development was accompanied with a change in the circadian rhythm of running-activity; e.g., the running-activity of the L-phase was higher than that of the D-phase. This phenomenon was more marked in the L-phase feeding group than in the D-phase feeding group. In addition, the ulcer development was closely related to body weight loss. No sex differences were found in these phenomena. The results suggest that change in the circadian rhythm of running-activity, body weight loss and high running-activity are important variables for predicting the A-S ulcer production, avoiding the need to kill the animals to determine ulcer formation.
在本研究中，我们调查了活动应激（A-S）溃疡的发生与采用A-S范式的大鼠行为和身体变化之间的关系。我们应用内窥镜技术建立A-S溃疡模型，用于研究溃疡的治疗或愈合过程。对雄性和雌性大鼠每日在光照期（09:00 - 10:00）或黑暗期（21:00 - 22:00）进行1小时喂食。在跑步活动达到峰值之前，光照期喂食组比黑暗期喂食组更早出现溃疡。溃疡的发生伴随着跑步活动昼夜节律的变化；例如，光照期的跑步活动高于黑暗期。这种现象在光照期喂食组比黑暗期喂食组更明显。此外，溃疡的发生与体重减轻密切相关。在这些现象中未发现性别差异。结果表明，跑步活动昼夜节律的变化、体重减轻和高跑步活动是预测A-S溃疡发生的重要变量，无需处死动物来确定溃疡形成。
