Doerries L E, Stanley E Z, Aravich P F
Department of Psychology, Christopher Newport College, Newport News, VA 23606.
Physiol Behav. 1991 Nov;50(5):945-9. doi: 10.1016/0031-9384(91)90419-o.
The phenomena of activity-based anorexia (ABA) and the activity-stress ulcer (ASU) both involve paradigms in which the food intake of rats is restricted and the animals are allowed voluntary exercise in a running wheel. This study determined the susceptibility of male and female rats to ABA and ASU following 25- and 30-percent losses of their original body weights. Male rats reached both weight loss criteria in a fewer number of days than did female rats. None of the male and female rats sacrificed at the 25% weight loss criterion evidenced gastric lesions; 52% of the animals sacrificed at the 30% weight loss criterion had one or more lesions. No gender differences with respect to gastric lesions were observed at the 30% weight loss criterion; however, at both weight loss criteria, females ate and ran more than males. It is concluded that ASUs are a consequence rather than a cause of ABA, and that there is a sexually "dimorphic" susceptibility to ABA but not ASUs. The utility of using a 25% weight loss criterion for defining ABA is also discussed.
基于活动的厌食症（ABA）和活动应激性溃疡（ASU）现象都涉及这样的实验范式：限制大鼠的食物摄入量，并让动物在跑轮上进行自愿运动。本研究确定了雄性和雌性大鼠在体重减轻其原始体重的25%和30%后对ABA和ASU的易感性。雄性大鼠达到两种体重减轻标准所需的天数比雌性大鼠少。在体重减轻25%标准时处死的雄性和雌性大鼠均未出现胃部病变；在体重减轻30%标准时处死的动物中有52%有一个或多个病变。在体重减轻30%标准时未观察到胃部病变的性别差异；然而，在两种体重减轻标准下，雌性大鼠的进食量和运动量均多于雄性大鼠。得出的结论是，ASU是ABA的结果而非原因，并且对ABA存在性别“二态性”易感性，但对ASU不存在。还讨论了使用25%体重减轻标准来定义ABA的实用性。
