Ohta H, Hokama H, Fukao K, Hirano K, Ogura C
Department of Neuropsychiatry, University of the Ryukyus.
Seishin Shinkeigaku Zasshi. 1993;95(6):439-52.
There have been many reports on the Event-Related Potentials (ERPs) abnormalities, especially P300 amplitudes reduction, in schizophrenic patients. However the relationships between P300 abnormalities and schizophrenic subtypes have not been clarified. This study aims to investigate the relationships in a relatively large number of drug free schizophrenics. Seventy three unmedicated schizophrenic patients (45 males, 28 females) who met the DSM-III-R criteria for schizophrenia were tested. Twenty seven of the schizophrenics were paranoid type according to the DSM-III-R, 23 were undifferentiated, 19 were disorganized, 2 catatonic and 2 residual. Seventy three healthy controls were age and gender matched to the patient group. All the ERPs were recorded during auditory odd ball task. Stimuli consists of 2 kHz and 1 kHz tone bursts, and the respective probabilities of the rare and frequent stimuli were 0.2 and 0.8. They were presented random order. The duration of each stimulus was 90 msec with rise and fall times of 10 msec, and the intensity was approximately 70 dB SPL for all the stimuli. The inter-stimulus intervals were 1.7 +/- 0.1 seconds. The subjects were instructed to count the numbers of rare tones. The scalp EEGs were recorded from Ag-AgCl electrodes at 16 sites that referred to linked earlobes. P300 amplitudes reduction [F (1,144) = 39.33, p < 0.001] and P300 latencies prolongation [F (1,144) = 12.41, p < 0.001] were found in schizophrenic group as a whole. Lower amplitude of P300 was observed at both right and left temporal sites in the subjects with undifferentiated type and disorganized type. Although in the subjects with paranoid type, the reduction was recognized at left temporal region, reduced amplitude was not seen at right temporal site. While no relationships between P300 amplitudes, the score of BPRS and SAPS were detected, in the patient with paranoid type, significant negative correlation between P300 amplitudes and SANS total scores was observed (r = -0.425, p = 0.03) at Pz site. These results were discussed with respect to cognitive impairment of schizophrenia.
已有许多关于精神分裂症患者事件相关电位（ERP）异常的报道，尤其是P300波幅降低。然而，P300异常与精神分裂症亚型之间的关系尚未明确。本研究旨在对相对大量未服药的精神分裂症患者进行调查，以研究两者之间的关系。对73例符合DSM-III-R精神分裂症标准的未服药精神分裂症患者（45例男性，28例女性）进行了测试。根据DSM-III-R标准，其中27例为偏执型精神分裂症患者，23例为未分化型，19例为紊乱型，2例为紧张型，2例为残留型。73名健康对照者在年龄和性别上与患者组相匹配。所有ERP均在听觉odd ball任务期间记录。刺激由2kHz和1kHz的短音组成，罕见刺激和频繁刺激的各自概率分别为0.2和0.8。它们以随机顺序呈现。每个刺激的持续时间为90毫秒，上升和下降时间为10毫秒，所有刺激的强度约为70dB SPL。刺激间隔为1.7±0.1秒。受试者被要求数出罕见音调的数量。头皮脑电图通过16个Ag-AgCl电极记录，参考双侧耳垂。总体精神分裂症组发现P300波幅降低[F（1,144）=39.33，p<0.001]和P300潜伏期延长[F（1,144）=12.41，p<0.001]。未分化型和紊乱型受试者在右侧和左侧颞叶部位均观察到P300波幅较低。虽然偏执型受试者在左侧颞叶区域发现波幅降低，但在右侧颞叶部位未发现波幅降低。虽然未检测到P300波幅与BPRS和SAPS评分之间的关系，但在偏执型患者中，在Pz部位观察到P300波幅与SANS总分之间存在显著负相关（r=-0.425，p=0.03）。针对精神分裂症的认知损害对这些结果进行了讨论。
