Belchi-Hernandez J, Florido-Lopez J F, Estrada-Rodriguez J L, Martinez-Alzamora F, Lopez-Serrano C, Ojeda-Casas J A
Department of Allergy, La Paz Hospital, Madrid, Spain.
Ann Allergy. 1993 Sep;71(3):230-2.
Metabisulfite sensitivity is being described with growing frequency. Sulfites are used in food, drinks, and drugs. Adverse reactions to apparently nontoxic doses have been described. Exposure of sensitive persons to sulfites has produced asthma, and occasionally other adverse reactions in nonasthmatic patients. We present a case of urticaria induced by metabisulfites. During the previous 2 years the patient had suffered episodes of urticaria and angioedema limited to the face, neck, upper thorax, and dysphonia without asthma after the ingestion of food and drinks containing sulfites. Oral challenge with 25 mg of potassium metabisulfite elicited urticaria on the face and neck, nasal itching, rhinorrhea, and dysphonia. Prick and intradermal tests were negative. Two further challenges with the same doses were also positive. One of these was controlled with placebo, 30 minutes after oral administration of 400 mg sodium cromolyn; the second was carried out 90 minutes after oral administration of 5000 micrograms cyanocobalamin. We have been unable to identify a pathogenic mechanism.
亚硫酸氢盐敏感性的报道日益增多。亚硫酸盐被用于食品、饮料和药物中。已有关于对明显无毒剂量产生不良反应的描述。敏感个体接触亚硫酸盐后会引发哮喘，非哮喘患者偶尔也会出现其他不良反应。我们报告一例由亚硫酸氢盐诱发的荨麻疹病例。在过去两年中，该患者在摄入含亚硫酸盐的食物和饮料后，出现了局限于面部、颈部、上胸部的荨麻疹和血管性水肿发作，伴有声音嘶哑，但无哮喘症状。口服25毫克亚硫酸氢钾激发试验引发了面部和颈部荨麻疹、鼻痒、流涕及声音嘶哑。点刺试验和皮内试验均为阴性。另外两次相同剂量的激发试验也呈阳性。其中一次在口服400毫克色甘酸钠30分钟后用安慰剂对照；第二次在口服5000微克氰钴胺90分钟后进行。我们尚未确定其致病机制。
