Sokol W N, Hydick I B
Ann Allergy. 1990 Sep;65(3):233-8.
A case of metabisulfite-induced anaphylaxis is presented in which convincing evidence of an IgE-mediated mechanism of action was found. The patient demonstrated urticaria, angioedema, nasal congestion, and apparent nasal polyp swelling following provocative challenge with sodium metabisulfite. Skin test to metabisulfite was positive as was a basophil histamine release test when the patient's cells were incubated with metabisulfite. A review of metabisulfite-induced allergic reactions in which an IgE-mediated mechanism has been demonstrated is presented.
本文报告了一例亚硫酸氢盐诱发的过敏反应病例，其中发现了IgE介导的作用机制的确凿证据。患者在接受亚硫酸氢钠激发试验后出现荨麻疹、血管性水肿、鼻充血以及明显的鼻息肉肿胀。对亚硫酸氢盐进行皮肤试验呈阳性，当患者的细胞与亚硫酸氢盐一起孵育时，嗜碱性粒细胞组胺释放试验也呈阳性。本文还综述了已证实存在IgE介导机制的亚硫酸氢盐诱发的过敏反应。
