Perry T L, Guyatt G H
Can Med Assoc J. 1977 Feb 5;116(3):253-6.
Total amounts of antimicrobial drugs used to treat inpatients during 1975 were calculated for three Canadian general hospitals, one of them the principal teaching hospital of a medical school. Use of drugs was compared with that reported for Boston City Hospital during periods when antimicrobial therapy was and was not supervised by infectious disease consultants. Ampicillin, tetracyclines, cephalosporins, erythromycin and aminoglycosides for prophylactic oral administration were used excessively in the three hospitals. The degree of overuse was comparable to that at Boston City Hospital during years when drug use was uncontrolled. Overuse or improper choice of antimicrobial drug decreases the quality of patient care and increases its cost. More rigorous education is needed for both medical students and practising physicians in the rational use of antimicrobial drugs. Informal consultation with an infectious disease unit should be required before certain overly popular or toxic antibiotics are administered to hospitalized patients.
计算了1975年期间加拿大三家综合医院用于治疗住院患者的抗菌药物总量，其中一家是一所医学院的主要教学医院。将这些医院的药物使用情况与波士顿市医院在有和没有传染病顾问监督抗菌治疗期间报告的情况进行了比较。这三家医院预防性口服氨苄西林、四环素、头孢菌素、红霉素和氨基糖苷类药物的使用过量。过度使用的程度与波士顿市医院在药物使用不受控制的年份相当。抗菌药物的过度使用或选择不当会降低患者护理质量并增加成本。医学生和执业医师在合理使用抗菌药物方面都需要更严格的教育。在给住院患者使用某些过度流行或有毒的抗生素之前，应要求与传染病科进行非正式咨询。
