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头颈部鳞状细胞癌患者颈部的治疗

Treatment of the neck in patients with squamous cell carcinoma of the head and neck.

作者信息

Jesse R H, Fletcher G H

出版信息

Cancer. 1977 Feb;39(2 Suppl):868-72. doi: 10.1002/1097-0142(197702)39:2+<868::aid-cncr2820390724>3.0.co;2-n.

Abstract

A retrospective study of 702 patients with clinically positive nodes associated with squamous cell carcinoma of the oral cavity, supraglottic larynx, and hypopharynx observed from 1954 to 1968 was done. The policies of treatment for the neck were not standardized during those years. Three hundred eleven patients who survived 24 months with the primary lesion controlled were divided into two groups: 1) those whose neck was treated by surgery alone; and 2) those who had combined radiation therapy and surgery to the neck, to test the efficacy of the two forms of treatment. For the three sites, the recurrence rate in the necks for the surgically treated group was 14% for stage N1, 26% for N2 and 34% N3. Rates for the group receiving combined treatment were 2%, 11% and 25% respectively. Results of the study also showed that elective irradiation, 5,000 rads in five weeks, will prevent metastasis from occurring in the NO staged neck.

摘要

对1954年至1968年间观察到的702例口腔、声门上喉和下咽鳞状细胞癌伴临床阳性淋巴结患者进行了回顾性研究。在那些年里,颈部的治疗策略并不标准化。311例原发灶得到控制且存活24个月的患者被分为两组:1)仅接受手术治疗颈部的患者;2)颈部接受放疗和手术联合治疗的患者,以测试这两种治疗方式的疗效。对于这三个部位,手术治疗组颈部N1期的复发率为14%,N2期为26%,N3期为34%。联合治疗组的复发率分别为2%、11%和25%。研究结果还表明,选择性照射,五周内照射5000拉德,可预防NO分期颈部发生转移。

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