Kaufmann R A, Welch R A, Mutchnick M G
Department of Obstetrics and Gynecology, Hutzel Hospital Wayne State University School of Medicine, Detroit, Michigan.
Am J Reprod Immunol. 1993 Apr;29(3):171-5. doi: 10.1111/j.1600-0897.1993.tb00583.x.
The thymus-derived peptides, thymosin alpha 1 and thymosin beta 4, are believed to contribute to the maintenance of immune homeostasis. They are also associated with the hypothalamic-pituitary-adrenal-gonadal axis and may play a role in reproduction.
Patients were recruited from a university hospital setting. Eligible candidates were 24 to 38 years old who were being seen in an ovulation induction and in vitro fertilization program. Serial maternal serum thymosin alpha 1 and beta 4 levels were assayed preconceptual and then twice in the first trimester by ELISA in 28 women with known ovulation dates who successfully conceived as demonstrated by positive serum beta human chorionic gonadotropin (hCG). Thymosin alpha 1 and beta 4 serum levels for viable pregnancies (group I; N = 19) were compared to pregnancies that aborted (group II; N = 9) using repeated measures of multivariate analysis of variance (MANOVA). Periconceptional (preovulatory and early pregnancy) thymosin alpha 1 and beta 4 values between groups I and II were compared using repeated measure one-way ANOVA.
Thymosin alpha 1 levels from pregnancies that remained viable were significantly higher than those from pregnancies that spontaneously aborted. Preovulation thymosin alpha 1 levels also tended to be lower in pregnancies that subsequently aborted. Thymosin beta 4 levels were similar between the two groups.
Decreased maternal serum thymosin alpha 1 levels may be associated with periconceptional endocrine and/or immune disturbances preceding miscarriage.
胸腺衍生肽，即胸腺素α1和胸腺素β4，被认为有助于维持免疫稳态。它们还与下丘脑 - 垂体 - 肾上腺 - 性腺轴相关，可能在生殖中发挥作用。
从大学医院招募患者。符合条件的候选人年龄在24至38岁之间，正在接受排卵诱导和体外受精治疗。通过酶联免疫吸附测定法（ELISA），对28名已知排卵日期且血清β人绒毛膜促性腺激素（hCG）呈阳性证明成功受孕的女性，在受孕前以及孕早期进行两次检测，测定其血清胸腺素α1和β4的系列水平。使用重复测量多变量方差分析（MANOVA），将活产妊娠组（第一组；N = 19）的胸腺素α1和β4血清水平与流产妊娠组（第二组；N = 9）进行比较。使用重复测量单因素方差分析，比较第一组和第二组之间受孕前后（排卵前和孕早期）的胸腺素α1和β4值。
持续存活妊娠的胸腺素α1水平显著高于自然流产妊娠的水平。随后流产的妊娠中，排卵前胸腺素α1水平也往往较低。两组之间胸腺素β4水平相似。
孕妇血清胸腺素α1水平降低可能与流产前受孕前后的内分泌和/或免疫紊乱有关。
