Welch R A, Mutchnick M G, Weller F E, Sokol R J
Am J Reprod Immunol Microbiol. 1987 Apr;13(4):125-7. doi: 10.1111/j.1600-0897.1987.tb00108.x.
The thymus directs T-lymphocyte development and contributes to the maintenance of immune homeostasis, in part, through its production of peptides known as thymosins. In pregnancy, maternal serum levels of thymosin alpha 1 have been reported to be low at midgestation and to increase by term, suggesting that maternal levels represent fetal levels. To evaluate this further, we obtained maternal venous and newborn mixed cord blood from 90 pregnancies between 20 and 42 weeks of gestation at delivery. An ELISA was used for thymosin alpha 1 assay, and analysis was by paired t test and regression. Maternal and newborn levels were independent of gestational age, but an apparent association (r = 0.51) between the two was inconclusive. Maternal levels (1,207 +/- 947 pg/ml) tended to be higher than those of healthy adults (1,043 +/- 576 pg/ml). Mixed umbilical cord serum levels (1,466 +/- 940 pg/ml) were higher than maternal levels (P less than or equal to 0.005). Although maternal thymosin alpha 1 levels may reflect fetal levels, immunological perturbations related to parturition appear to influence both.
胸腺指导T淋巴细胞的发育，并在一定程度上通过产生称为胸腺素的肽来维持免疫稳态。据报道，在怀孕期间，孕中期母体血清中α1胸腺素水平较低，足月时升高，这表明母体水平代表胎儿水平。为了进一步评估这一点，我们在分娩时从90例妊娠20至42周的孕妇中获取了母体静脉血和新生儿脐血混合样本。采用ELISA法检测α1胸腺素，分析采用配对t检验和回归分析。母体和新生儿的水平与胎龄无关，但两者之间明显的关联（r = 0.51）尚无定论。母体水平（1,207 +/- 947 pg/ml）往往高于健康成年人（1,043 +/- 576 pg/ml）。脐血混合血清水平（1,466 +/- 940 pg/ml）高于母体水平（P≤0.005）。尽管母体α1胸腺素水平可能反映胎儿水平，但与分娩相关的免疫扰动似乎对两者都有影响。
