Welch R A, Lee H H, Sokol R J, Mutchnick M G
Department of Obstetrics and Gynecology, Wayne State University/Hutzel Hospital, Detroit, MI 48201.
Am J Reprod Immunol Microbiol. 1988 Jul;17(3):96-7. doi: 10.1111/j.1600-0897.1988.tb00210.x.
Thymosin alpha 1 is one of several cytokines produced by the thymus that modulates immune function. The presence of elevated serum levels of thymosin alpha 1 in pregnant women and their newborns has suggested that this peptide may play a role in perinatal immunology. In this investigation, we used a microenzyme-linked immunosorbent assay to assay amniotic fluid for immunoreactive thymosin alpha 1 and found levels that were remarkably higher than newborn serum levels (P less than 10(-4]. The increase of thymosin alpha 1 in amniotic fluid with fetal age was natural logarithmic (r = 0.838, P less than 10(-6]. Thymosin alpha 1 in amniotic fluid may account for some of the immunologic properties of this medium.
胸腺肽α1是胸腺产生的几种调节免疫功能的细胞因子之一。孕妇及其新生儿血清中胸腺肽α1水平升高表明，这种肽可能在围产期免疫学中发挥作用。在本研究中，我们使用微量酶联免疫吸附测定法检测羊水内的免疫反应性胸腺肽α1，发现其水平显著高于新生儿血清水平（P<10⁻⁴）。羊水内胸腺肽α1水平随胎龄增加呈自然对数增长（r = 0.838，P<10⁻⁶）。羊水内的胸腺肽α1可能是该介质某些免疫特性的原因。
