Gerken T A
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106.
Crit Rev Oral Biol Med. 1993;4(3-4):261-70. doi: 10.1177/10454411930040030201.
Our understanding of the origins of the physical and biochemical properties of mucous glycoproteins is incomplete and not with out controversy. Recent molecular biological and biophysical studies revealing the architecture and solution structure and dynamics of a series of salivary mucins, invaluable toward resolving many of these questions, are discussed. Mucins are very large, structurally heterogeneous, and highly expanded molecules with the carbohydrate playing a key role in maintaining the extended mucin conformation.
我们对黏液糖蛋白物理和生化特性起源的理解并不完整，且存在争议。本文讨论了近期的分子生物学和生物物理研究，这些研究揭示了一系列唾液黏蛋白的结构、溶液结构和动力学，对解决其中许多问题具有重要价值。黏蛋白是非常大的、结构异质的且高度伸展的分子，其中碳水化合物在维持黏蛋白伸展构象中起关键作用。
