Berezov T T
Biull Eksp Biol Med. 1993 Jun;115(6):600-2.
There is indirect evidence that key enzymes which catalyse both synthesis and degradation of polyamines (PA) may be useful as biological markers of malignant growth. Ornithine decarboxylase (ODC) activity was assessed in fetal, regenerating and adult rat liver, in hepatoma with different growth rate, in Morris hepatoma cell lines and in rat liver in the course of nitrosopiperidine (NP) carcinogenesis. A much higher ODC activity was observed in all the investigated tumor tissues and in regenerating rat liver as well. A significant decrease of ODC inductive synthesis was demonstrated both in liver and hepatoma of rats maintained on vitamin B6-deficient diet. The experimental suggest that inductive synthesis of ODC may be considered not only early, but also the mandatory event in any hyperproliferating processes including carcinogenesis.
有间接证据表明，催化多胺（PA）合成与降解的关键酶可能作为恶性生长的生物学标志物。在胎儿、再生和成年大鼠肝脏、不同生长速率的肝癌、莫里斯肝癌细胞系以及亚硝基哌啶（NP）致癌过程中的大鼠肝脏中评估了鸟氨酸脱羧酶（ODC）活性。在所有研究的肿瘤组织以及再生大鼠肝脏中也观察到了更高的ODC活性。在维生素B6缺乏饮食喂养的大鼠的肝脏和肝癌中，ODC诱导合成均显著降低。实验表明，ODC的诱导合成不仅可能是任何包括致癌作用在内的过度增殖过程中的早期事件，而且是必需事件。
