Siatkin S P, Berezov T T
Vopr Med Khim. 1980 Jan-Feb;26(1):121-4.
Activity of ornithine decarboxylase was studied in transplantable hepatomas G-27, G-22, G-61, G-60, G-48, G-46, in liver tissues of tumor-bearing and intact animals as well as in liver tissue during hepatocarcinogenesis and after repeated administration of nitrose piperidine. The rate of ornithine decarboxylation was distinctly increased in hepatomas G-27, G-60, G-46 and G-48 as compared with liver tissue of tumor-bearing and intact animals. The enzymatic activity in hepatomas G-22 and G-61 was similar to the activity found in liver tissue of intact animals. In liver tissue of tumor-bearing animals the enzyme activity was significantly increased only in hepatoma 22. Repeated administration of nitrose piperidine did not affect the ornithine decarboxylase activity in rat liver tissue. The carcinogenesis, caused by nitrosamine effect, increased distinctly the enzymatic activity in rat liver tissue up to the moment of the primary hepatomas development.
对可移植性肝癌G - 27、G - 22、G - 61、G - 60、G - 48、G - 46、荷瘤动物和正常动物的肝脏组织以及肝癌发生过程中及反复给予硝基亚硝基哌啶后的肝脏组织中的鸟氨酸脱羧酶活性进行了研究。与荷瘤动物和正常动物的肝脏组织相比，肝癌G - 27、G - 60、G - 46和G - 48中的鸟氨酸脱羧速率明显增加。肝癌G - 22和G - 61中的酶活性与正常动物肝脏组织中的活性相似。在荷瘤动物的肝脏组织中，仅在肝癌22中酶活性显著增加。反复给予硝基亚硝基哌啶对大鼠肝脏组织中的鸟氨酸脱羧酶活性没有影响。由亚硝胺作用引起的致癌作用，在原发性肝癌发生前明显增加了大鼠肝脏组织中的酶活性。
