Marcus F I, Quinn E J, Horton H, Jacobs S, Pippin S, Stafford M, Zukoski C
Circulation. 1977 Mar;55(3):537-41. doi: 10.1161/01.cir.55.3.537.
Seven subjects who underwent jejunoileal bypass surgery for massive obesity participated in a study to examine the relative bioavailability of digoxin before and one to two months after surgery. They were given a loading dose of 1 mg digoxin in divided oral doses followed by oral maintenance doses of 0.5 mg daily. There were no significant differences in the area under the serum concentration time curve, steady state serum levels or 24 hour steady state excretion of digoxin before and after surgery. We conclude that the bioavailability of digoxin from the Lanoxin tablets employed is not impaired in these patients, although urinary d-xylose and 24 hour fecal fat excretion indicated moderate to severe malabsorption after surgery.
七名因极度肥胖接受空肠回肠分流术的受试者参与了一项研究，以检测手术前及术后一至两个月地高辛的相对生物利用度。他们口服了1毫克地高辛的负荷剂量，分几次服用，随后每日口服维持剂量0.5毫克。手术前后地高辛的血清浓度-时间曲线下面积、稳态血清水平或24小时稳态排泄量均无显著差异。我们得出结论，尽管术后尿中d-木糖和24小时粪便脂肪排泄表明存在中度至重度吸收不良，但在这些患者中，所用的地高辛片剂的生物利用度并未受损。
