Thompson P W, Whittaker J A, Brennan H
Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, United Kingdom.
Cancer Genet Cytogenet. 1993 Aug;69(1):41-4. doi: 10.1016/0165-4608(93)90111-x.
We report on three further cases of trisomy 4 in acute nonlymphocytic leukemia. In one case the trisomy 4 was accompanied by double minute (dmin) chromosomes. Of the 34 reports of trisomy 4, dmin were also found in five cases, showing a clear nonrandom association between the two cytogenetic abnormalities.
我们报告了另外三例急性非淋巴细胞白血病中4号染色体三体的病例。其中一例4号染色体三体伴有双微体(dmin)染色体。在已报道的34例4号染色体三体病例中,有5例也发现了双微体,表明这两种细胞遗传学异常之间存在明显的非随机关联。