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急性非淋巴细胞白血病伴双微体染色体的4三体综合征

Trisomy 4 with double minute chromosomes in acute nonlymphocytic leukemia.

作者信息

Thompson P W, Whittaker J A, Brennan H

机构信息

Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, United Kingdom.

出版信息

Cancer Genet Cytogenet. 1993 Aug;69(1):41-4. doi: 10.1016/0165-4608(93)90111-x.

DOI:10.1016/0165-4608(93)90111-x
PMID:8374899
Abstract

We report on three further cases of trisomy 4 in acute nonlymphocytic leukemia. In one case the trisomy 4 was accompanied by double minute (dmin) chromosomes. Of the 34 reports of trisomy 4, dmin were also found in five cases, showing a clear nonrandom association between the two cytogenetic abnormalities.

摘要

我们报告了另外三例急性非淋巴细胞白血病中4号染色体三体的病例。其中一例4号染色体三体伴有双微体(dmin)染色体。在已报道的34例4号染色体三体病例中,有5例也发现了双微体,表明这两种细胞遗传学异常之间存在明显的非随机关联。

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