Donti E, Maccari A, Tabilio A, Ardisia C, Campanari N, Donti G V
First Department of Internal Medicine, University of Perugia, Italy.
Cancer Genet Cytogenet. 1992 Jun;60(2):195-7. doi: 10.1016/0165-4608(92)90018-4.
Two patients with M2 subtype of acute nonlymphocytic leukemia (ANLL) and trisomy 4 as a primary karyotype change are described. The abnormality was observed in 100% of bone marrow (BM) metaphases in both cases. It appeared alone in one case and was associated with trisomy 13 in 94% of metaphases in the other. These are the second and third cases of ANLL with trisomy 4 documented in Italy. Neither patient appears to have incurred any environmental or therapeutic insult.
本文描述了两名急性非淋巴细胞白血病（ANLL）M2亚型患者，其主要核型变化为4号染色体三体。在这两例患者中，100%的骨髓中期细胞均观察到该异常。其中一例异常单独出现，另一例中94%的中期细胞该异常与13号染色体三体相关。这是意大利记录的第二例和第三例伴有4号染色体三体的ANLL病例。两名患者似乎均未受到任何环境或治疗性损伤。
