Goldberg D M, Martin J V, Knight A H
Clin Biochem. 1977 Feb;10(1):8-11. doi: 10.1016/s0009-9120(77)90116-3.
Of 101 consecutive hospitalised diabetic patients, 29 had elevated serum enzyme activities attributable to recognized clinical entities; 17% of the remainder had raised alkaline phosphatase (AP) activity, 15% had raised aspartate aminotransferase (GOT) activity, and 12% raised lactate dehydrogenase (LDH) activity in serum. Ketoacidosis and death within 3 months were commoner among patients with elevated serum enzyme activities than among those with normal enzymes. Study of 200 consecutive new untreated diabetics when first seen at an out-patient clinic revealed 15 with clinically explainable abnormal serum enzyme activities. Of the remainder, 11% had raised AP activity, 12% raised GOT activity, and 21% raised LDH activity in serum; these patients tended to have higher blood sugar concentrations than the subjects with normal serum enzymes. These abnormalities seem to be an intrinsic feature of diabetes mellitus which do not relate to duration, complications, or treatment of the disease. They do not seem to be directly related to hepatic involvement.
在连续收治的101例糖尿病住院患者中，29例血清酶活性升高可归因于已确认的临床病症；其余患者中，17%碱性磷酸酶（AP）活性升高，15%天冬氨酸转氨酶（GOT）活性升高，12%血清乳酸脱氢酶（LDH）活性升高。血清酶活性升高的患者在3个月内发生酮症酸中毒和死亡的情况比酶正常的患者更为常见。对连续200例初诊时在门诊首次就诊的未经治疗的糖尿病患者进行研究发现，15例患者血清酶活性异常具有临床可解释性。在其余患者中，11% AP活性升高，12% GOT活性升高，21%血清LDH活性升高；这些患者的血糖浓度往往高于血清酶正常的受试者。这些异常似乎是糖尿病的固有特征，与疾病的病程、并发症或治疗无关。它们似乎与肝脏受累没有直接关系。
