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I型糖尿病患者对钙输注的钙及降钙素反应

Calcium and calcitonin responses to calcium infusion in type I diabetes mellitus.

作者信息

Amado J A, Gomez C, Obaya S, Otero M, Gonzalez-Macias J

机构信息

Department of Internal Medicine, Valdecilla Hospital School of Medicine, Santander, Spain.

出版信息

Postgrad Med J. 1987 Apr;63(738):249-52. doi: 10.1136/pgmj.63.738.249.

DOI:10.1136/pgmj.63.738.249
PMID:3684831
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2428141/
Abstract

We studied calcium and calcium and calcitonin responses to intravenous calcium infusion (3 mg of elemental calcium/kg of body weight in 10 minutes) in 21 type I diabetic males and 17 age-matched normal males. Baseline total calcium, parathyroid hormone and calcitonin levels were normal in the diabetic group, but ionized calcium was lowered. Cortical bone status and osteocalcin levels were normal, suggesting a normal osteoblastic function. Total calcium and ionized calcium responses to calcium infusion were lowered in the diabetic group. Despite these lowered calcaemic responses, calcitonin secretion was normal.

摘要

我们研究了21名I型糖尿病男性和17名年龄匹配的正常男性对静脉注射钙剂（10分钟内每千克体重注射3毫克元素钙）的钙、钙和降钙素反应。糖尿病组的基线总钙、甲状旁腺激素和降钙素水平正常，但离子钙降低。皮质骨状态和骨钙素水平正常，提示成骨细胞功能正常。糖尿病组对钙剂注射的总钙和离子钙反应降低。尽管这些血钙反应降低，但降钙素分泌正常。

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引用本文的文献

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Serum calcium in diabetes.
Calcif Tissue Int. 1990 Oct;47(4):257. doi: 10.1007/BF02555929.

本文引用的文献

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Hypoparathyroidism in diabetes mellitus.糖尿病中的甲状旁腺功能减退症。
Acta Endocrinol (Copenh). 1981 Jan;96(1):81-6. doi: 10.1530/acta.0.0960081.
2
Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone.血浆中维生素K依赖骨蛋白的来源及其经肾脏和骨骼的清除。
J Biol Chem. 1981 Dec 25;256(24):12760-6.
3
Use of oral calcium loading to characterize the hypercalciuria of young insulin-dependent diabetics.使用口服钙负荷来表征年轻胰岛素依赖型糖尿病患者的高钙尿症。
J Clin Endocrinol Metab. 1983 Jul;57(1):94-100. doi: 10.1210/jcem-57-1-94.
4
Basal and calcium stimulated serum calcitonin in insulin-dependent diabetics.胰岛素依赖型糖尿病患者的基础及钙刺激血清降钙素
Horm Metab Res. 1984 Feb;16(2):100-1. doi: 10.1055/s-2007-1014707.
5
Lowered serum ionized calcium in insulin treated diabetic subjects.胰岛素治疗的糖尿病患者血清离子钙降低。
Scand J Clin Lab Invest Suppl. 1983;165:93-7.
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Deficient calcitonin response to calcium stimulation in postmenopausal osteoporosis?绝经后骨质疏松症中降钙素对钙刺激的反应不足？
Lancet. 1982 Feb 27;1(8270):475-8. doi: 10.1016/s0140-6736(82)91451-9.
7
Effect of silicone-separator tubes and storage time on ionized calcium in serum.硅胶分离管和储存时间对血清中离子钙的影响。
Clin Chem. 1985 Jan;31(1):169-70.
8
Effects of diabetes mellitus on bone mass in juvenile and adult-onset diabetes.糖尿病对青少年和成人发病型糖尿病骨量的影响。
N Engl J Med. 1976 Jan 29;294(5):241-5. doi: 10.1056/NEJM197601292940502.
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Elevation of serum alkaline phosphatase activity and related enzymes in diabetes mellitus.糖尿病患者血清碱性磷酸酶活性及相关酶的升高。
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Osteopenia in insulin treated diabetes mellitus. Its relation to age at onset, sex and duration of disease.胰岛素治疗的糖尿病中的骨质减少。其与发病年龄、性别及病程的关系。
Diabetologia. 1978 Aug;15(2):87-90. doi: 10.1007/BF00422250.

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