Blasco-Casares F J, Saladié-Roig J M, Encabo-Mayoral B, Comet-Batllé J
Department of Urology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain.
Eur Urol. 1993;24(2):291-6. doi: 10.1159/000474312.
We took 7 dogs to undergo thorough autotransplant of the ureter as an autologous nonvascularized free graft, after having obtained good results with rats. The steps followed in these 7 dogs were the removal of a 10- to 12-cm segment of the ureter and the replantation of the same segment to the same animal. We must point out that both anastomoses were performed with interrupted sutures. Although some complications such as stenosis occurred, urographic studies showed that some animals kept their renal function for over 8 months after autotransplantation. Using contrast, we were able to observe the ureter. Similarly, we observed peristaltic waves on the ureters which were always dilated. Histologic studies showed preservation of the ureteral layers with hyperplasia of the ureteral mucosa, greater or lesser degree of submucosal fibrosis, and a variable degree of hyperplasia or muscular atrophy. Extensive areas of bone metaplasia were observed in some animals.
在大鼠实验取得良好结果后，我们选取了7只狗进行输尿管的自体非血管化游离移植的彻底自体移植。在这7只狗身上采取的步骤是切除一段10至12厘米长的输尿管，并将同一段输尿管重新移植到同一只动物体内。我们必须指出，两个吻合口均采用间断缝合。尽管出现了一些并发症，如狭窄，但尿路造影研究表明，一些动物在自体移植后肾功能保持了8个多月。通过造影剂，我们能够观察输尿管。同样，我们观察到输尿管上总是扩张的蠕动波。组织学研究显示输尿管各层得以保留，输尿管黏膜增生，黏膜下纤维化程度有大有小，肌肉增生或萎缩程度不一。在一些动物中观察到广泛的骨化生区域。
