Kurz C, Nagele F, Sevelda P, Enzelsberger H
1. Universitäts-Frauenklinik Wien.
Geburtshilfe Frauenheilkd. 1993 Aug;53(8):535-8. doi: 10.1055/s-2007-1022929.
Local intravaginal application of oestriol is part of the therapeutical programme of sensory urge-incontinence. The effectiveness of a new method--intravesical administration of 1 mg oestriol versus a placebo--has been proved in a prospective randomised study. 21 patients each were treated over a period of three weeks with oestriol or with the placebo-substance intravesically. The effectiveness of the administered therapy was checked with clinical and urodynamic parameters. The intravesical administration of 1 mg oestriol proved to be efficient and free of side effects in respect of the parameters such as imperative micturition, bladder capacity, of the maximum urethral closure pressure as well as the number of micturitions per diem. The intravesical administration of oestriol may be considered as additional method of therapy for treatment of sensory urge-incontinence.
局部阴道内应用雌三醇是感觉性尿急失禁治疗方案的一部分。一项前瞻性随机研究证实了一种新方法——膀胱内给予1毫克雌三醇与安慰剂相比——的有效性。每组21例患者接受为期三周的膀胱内雌三醇或安慰剂治疗。通过临床和尿动力学参数检查所给予治疗的有效性。就迫切性排尿、膀胱容量、最大尿道闭合压以及每日排尿次数等参数而言，膀胱内给予1毫克雌三醇被证明是有效的且无副作用。膀胱内给予雌三醇可被视为治疗感觉性尿急失禁的一种额外治疗方法。
