Gassner K, Briel R C
Ehem. Landesfrauenklinik Stuttgart, Universitäts-Frauenklinik Tübingen.
Geburtshilfe Frauenheilkd. 1988 Aug;48(8):562-6. doi: 10.1055/s-2008-1026539.
In a prospective study, 31 unselected patients with urge or urge incontinence, where previous treatment had been unsuccessful, were given repeated instillations of Lidocain gel for 11 days. Detailed histories were obtained by questionnaire both before instituting and after termination of the therapy. A cystourethrotonometric examination was also performed by the microtransducer method. The urge symptoms improved in almost all the patients. There was also a distinct improvement in subjective feelings of incontinence. There was a statistically significant reduction in mean micturition frequency. In 50% of the patients it was no longer possible to detect hypertonic bladder tone and pathologic detrusor contractions by cystourethrotonometry. Patients who had had lower bladder capacity prior to therapy showed a tendency to increased capacity after treatment. While there was no change in functional urethral length, there was a significant increase in maximum urethral closing pressure. Tonometrically detectable stress incontinence disappeared in one-fourth of the patients. No side effects were observed. In view of the high rate of success and the acceptance of intravesicular Lidocain therapy, it can also be recommended for cases resistant to therapy and, if necessary, can be included in an all-embracing therapeutic concept for urge incontinence.
在一项前瞻性研究中，对31例未经挑选的尿急或急迫性尿失禁患者（先前治疗均未成功）进行了为期11天的利多卡因凝胶重复灌注。在治疗开始前和结束后，通过问卷调查获取详细病史。还采用微传感器方法进行了膀胱尿道压力测定检查。几乎所有患者的尿急症状均有改善。尿失禁的主观感受也有明显改善。平均排尿频率有统计学意义的降低。通过膀胱尿道压力测定法，50%的患者不再能检测到高张性膀胱张力和病理性逼尿肌收缩。治疗前膀胱容量较低的患者治疗后有容量增加的趋势。虽然功能性尿道长度没有变化，但最大尿道闭合压有显著增加。通过压力测定可检测到的压力性尿失禁在四分之一的患者中消失。未观察到副作用。鉴于膀胱内利多卡因治疗的高成功率和可接受性，它也可推荐用于治疗抵抗的病例，如有必要，可纳入急迫性尿失禁的综合治疗方案。
