Schmauss M, Erfurth A
Bezirkskrankenhaus Augsburg.
Fortschr Neurol Psychiatr. 1993 Aug;61(8):274-83. doi: 10.1055/s-2007-999095.
Although antidepressants have been available for over 35 years, it is not possible to accurately predict the response to this kind of treatment. This article reviews both clinical and biological predictors of treatment response. Among the clinical predictors chronicity of depression, high neuroticism and psychotic features are associated with poor response. Tricyclic antidepressants remain the drugs of choice in "endogenous" depression, whereas monoamine oxidase inhibitors play an important role in the treatment of atypical depression. Biological predictors of response, despite a lot of interesting findings that may be important for the future, are not yet sufficiently established for clinical practicability.
尽管抗抑郁药已经问世超过35年，但仍无法准确预测对这类治疗的反应。本文综述了治疗反应的临床和生物学预测因素。在临床预测因素中，抑郁的慢性化、高神经质和精神病性特征与反应不佳相关。三环类抗抑郁药仍是“内源性”抑郁的首选药物，而单胺氧化酶抑制剂在非典型抑郁的治疗中发挥重要作用。尽管有许多可能对未来很重要的有趣发现，但反应的生物学预测因素在临床实用性方面尚未得到充分确立。
