Baty J D, Robinson P R
Clin Pharmacol Ther. 1977 Feb;21(2):177-86. doi: 10.1002/cpt1977212177.
A new method for the investigation of interindividual differences in drug metabolism is described. We have studied the metabolism of ring-deuterated acetanilid in man following the coadministration of phenacetin. The principal metabolite of acetanilid-d5 is acetaminophen-d4, and the principal metabolite of phenacetin is acetaminophen-do. Using a gas chromatograph--mass spectrometer (gc-ms) we are able to monitor both the devterion-labeled acetaminophen produced by hydroxylation of acetanilid-d5 and the nonlabeled material produced by oxidative removal of the ethyl group in phenacetin. This system allows us to detect differences in the handling of these drugs by different subjects. nonlabeled material produced by oxidative removal of the ethyl group in phenacetin. This system allows us to detect differences in the handling of these drugs by different subjects.
本文描述了一种研究个体间药物代谢差异的新方法。我们研究了在同时给予非那西丁后，人体中环氘代乙酰苯胺的代谢情况。乙酰苯胺 -d5 的主要代谢产物是对乙酰氨基酚 -d4，非那西丁的主要代谢产物是对乙酰氨基酚 -d0。使用气相色谱 - 质谱联用仪（GC-MS），我们能够监测乙酰苯胺 -d5 羟基化产生的氘标记对乙酰氨基酚以及非那西丁中乙基氧化去除产生的未标记物质。该系统使我们能够检测不同受试者对这些药物处理方式的差异。非那西丁中乙基氧化去除产生的未标记物质。该系统使我们能够检测不同受试者对这些药物处理方式的差异。
