Benowitz N L, Jones R T
Clin Pharmacol Ther. 1977 Mar;21(3):336-42. doi: 10.1002/cpt1977213336.
In order to evaluate the possible effects of delta-9-tetrahydrocannabinol (THC) on autonomic nervous system function, cardiovascular responses to intravenous isoproterenol, phenylephrine, atropine, and propranolol were compared in hospitalized volunteers before and after 14 days of THC ingestion. There was no significant alteration in responses to isoproterenol or phenylephrine, although in one subject the pressor effect of phenylephrine was considerably augmented by THC. Heart rates after parasympathetic (atropine) blockade and after combined parasympathetic and sympathetic (propranolol) blockade were significantly greater during THC ingestion. These and other data presented are consistent with the picture of reduced sympathetic and enhanced parasympathetic activity described in animals on THC. During THC ingestion, atropine had a pronounced pressor effect, which might represent a clinically significant drug interaction.
为了评估δ-9-四氢大麻酚（THC）对自主神经系统功能的可能影响，在住院志愿者摄入THC 14天前后，比较了他们对静脉注射异丙肾上腺素、去氧肾上腺素、阿托品和普萘洛尔的心血管反应。对异丙肾上腺素或去氧肾上腺素的反应没有显著改变，尽管在一名受试者中，THC使去氧肾上腺素的升压作用显著增强。在摄入THC期间，副交感神经（阿托品）阻断后和副交感神经与交感神经联合（普萘洛尔）阻断后的心率显著更高。所呈现的这些以及其他数据与在动物身上描述的THC使交感神经活动降低和副交感神经活动增强的情况一致。在摄入THC期间，阿托品有明显的升压作用，这可能代表一种具有临床意义的药物相互作用。
