Bachman J A, Benowitz N L, Herning R I, Jones R T
Psychopharmacology (Berl). 1979 Mar 22;61(2):171-5. doi: 10.1007/BF00426733.
Intravenous THC, 30--44.8 microgram/kg, was administered to four subjects. Each received THC on four occasions preceded by either i.v. saline, 0.04 mg/kg atropine sulfate, 0.2 mg/kg propranolol, or both drugs together. Heart rates, subjective intoxication and symptom ratings, time productions, and EEG activity were measured. In the absence of autonomic blocking drugs, THC produced characteristic tachycardia, subjective intoxication, and EEG effects. After combined autonomic blockade, THC had no effect on heart rate, while subjective and EEG changes remained as intense. These findings argue against the hypothesis that the subjective and EEG effects of THC are mediated by autonomic receptors or by interoception of peripheral autonomic actions of THC.
给4名受试者静脉注射30 - 44.8微克/千克的四氢大麻酚（THC）。每名受试者在四次给药时，每次给药前分别注射静脉生理盐水、0.04毫克/千克硫酸阿托品、0.2毫克/千克普萘洛尔或两种药物联合注射。测量心率、主观中毒和症状评分、时间判断以及脑电图活动。在没有自主神经阻断药物的情况下，THC会产生典型的心动过速、主观中毒和脑电图效应。联合自主神经阻滞后，THC对心率没有影响，而主观和脑电图变化仍然强烈。这些发现与以下假设相悖，即THC的主观和脑电图效应是由自主神经受体介导的，或者是由THC外周自主神经作用的内感受介导的。
