Benowitz N L, Rosenberg J, Rogers W, Bachman J, Jones R T
Clin Pharmacol Ther. 1979 Apr;25(4):440-6. doi: 10.1002/cpt1979254440.
The contribution of autonomic nervous system activity to the cardiovascular effects of delta-9-tetrahydrocannabinol (THC) was evaluated in 4 normal subjects. The peak heart rate rise after THC was attenuated by atropine and by propranolol, and nearly abolished by atropine-propranolol pretreatment. Blocking drugs also attenuated THC-induced changes in forearm blood flow and vascular resistance but did not affect changes in fingertip temperature. The data suggest that THC acts to induce sympathetic stimulation and parasympathetic inhibition of cardiovascular control pathways. Cardiovascular responses in an additional subject who developed hypertension after either intravenous or smoked marijuana are described.
在4名正常受试者中评估了自主神经系统活动对Δ⁹-四氢大麻酚（THC）心血管效应的作用。THC后心率上升峰值被阿托品和普萘洛尔减弱，且在阿托品-普萘洛尔预处理后几乎完全消除。阻断药物也减弱了THC诱导的前臂血流和血管阻力变化，但不影响指尖温度变化。数据表明，THC作用于诱导心血管控制通路的交感神经刺激和副交感神经抑制。还描述了另外一名在静脉注射或吸食大麻后出现高血压的受试者的心血管反应。
