Vestal R E, McGuire E A, Tobin J D, Andres R, Norris A H, Mezey E
Clin Pharmacol Ther. 1977 Mar;21(3):343-54. doi: 10.1002/cpt1977213343.
The effect of aging on the distribution and elimination of ethanol was studied in a group of 50 healthy subjects ranging in age from 21 to 81 yr (mean, 53.3). Ethanol was administered in a continuous 1-hr infusion at a mean rate of 375 mg/m2 body surface area/min (equivalent to a mean dose of 0.57 gm/kg body weight). Serial blood samples for the determination of ethanol concentration was obtained at 15- to 30-min intervals for up to 4 hr post infusion. Ethanol elimination and distribution were evaluated with the aid of a two-compartment model. Rates of ethanol elimination were not affected by age. Peak ethanol concentration in blood water at the end of the infusion period was correlated with age (r= 0.55, p less than 0.001). Lean body mass and total volume of distirbution fo the ethanol were negatively correlated with age. The smaller volume of distirbution, in association with the decreased lean body mass, most likely explains the higher peak ethanol concentration found in the blood after administration of an ethanol does on the basis of surface area in the old as compared with the young subjects. This study demonstrates that age-related changes in body composition are important factors in the study of ethanol metabolism and its pharmacologic effects.
在一组年龄从21岁至81岁（平均53.3岁）的50名健康受试者中，研究了衰老对乙醇分布和消除的影响。乙醇以平均速率375毫克/平方米体表面积/分钟（相当于平均剂量0.57克/千克体重）进行连续1小时输注。在输注后长达4小时内，每隔15至30分钟采集系列血样以测定乙醇浓度。借助二室模型评估乙醇的消除和分布。乙醇消除速率不受年龄影响。输注期结束时血水中乙醇的峰值浓度与年龄相关（r = 0.55，p < 0.001）。瘦体重和乙醇分布总体积与年龄呈负相关。与年轻受试者相比，老年受试者分布体积较小，加上瘦体重减少，很可能解释了按体表面积给予乙醇剂量后血液中较高的乙醇峰值浓度。本研究表明，身体组成的年龄相关变化是乙醇代谢及其药理作用研究中的重要因素。
