Wells D, King J D, Roe T F, Kaufman F R
Division of Orthopaedic Surgery, Childrens Hospital Los Angeles, University of Southern California School of Medicine.
J Pediatr Orthop. 1993 Sep-Oct;13(5):610-4.
Review of type and bilaterality of 131 cases (40 bilateral) of slipped capital femoral epiphysis (SCFE) in patients with known endocrinopathies (hypothyroidism, panhypopituitarism, hypogonadism) from 1960 to 1990 showed an increased frequency of patients with endocrine disorders, primarily hypothyroidism (nine of 131 patients, 6.9%); three had bilateral slips; six developed bilateral slips in an average of 11.17 months. Delayed growth plate closure is common in SCFE. Because hypothyroidism can be easily overlooked, all patients with SCFE should be screened for hypothyroidism by measuring serum T4 and TSH (such screening is inexpensive (r = $60). Pituitary deficiency should be considered in children short for their age who have hypogonadism. Any child with a unilateral slip and one of these endocrine deficiencies has a high risk of subsequent bilateral involvement. Prophylactic pinning of the uninvolved hip is recommended because 100% of our patients eventually had bilateral slips.
对1960年至1990年已知患有内分泌疾病（甲状腺功能减退、全垂体功能减退、性腺功能减退）的131例（40例双侧）股骨头骨骺滑脱（SCFE）患者的类型和双侧性进行回顾，结果显示内分泌疾病患者的发生率增加，主要是甲状腺功能减退（131例患者中有9例，6.9%）；3例出现双侧滑脱；6例在平均11.17个月内发展为双侧滑脱。生长板闭合延迟在SCFE中很常见。由于甲状腺功能减退很容易被忽视，所有SCFE患者都应通过测量血清T4和TSH来筛查甲状腺功能减退（这种筛查费用低廉（约60美元））。对于性腺功能减退且年龄与其身高不符的儿童，应考虑垂体功能减退。任何单侧滑脱且患有这些内分泌缺陷之一的儿童，随后双侧受累的风险都很高。建议对未受累的髋关节进行预防性固定，因为我们所有的患者最终都出现了双侧滑脱。
