Gupta R K, Korte D W, Reddy G
Letterman Army Institute of Research, San Francisco, CA 94129-6800.
J Appl Toxicol. 1993 Jul-Aug;13(4):231-4. doi: 10.1002/jat.2550130404.
Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex-linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4-8 micrograms ml-1 and 15-20 mg ml-1, respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant.
通过使用果蝇性连锁隐性致死（SLRL）试验，评估了硝基胍（NG）及其降解产物亚硝基胍（NSG）的致突变潜力。经72小时喂食暴露后，浓度分别为4 - 8微克/毫升和15 - 20毫克/毫升的NG和NSG在测试系统中无致突变性。NG和阴性对照的突变频率分别为0.188%和0.096%。NSG和阴性对照实验的突变频率分别为0.049%和0.05%。两次试验的阳性对照突变频率分别为15%和17.8%。NG和NSG与其阴性对照的突变频率差异不显著。
